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This passageway allows for the movement of salt and water in and out of organs including the lungs to keep the airways hydrated and free of infection.
When the gene for CFTR proteins is mutated, major organs become susceptible to severe damage.
Two groundbreaking drugs were recently identified through a process called high-throughput screening, where hundreds of thousands of drug-like molecules are randomly applied to mutated cells until a combination works.
This leaves a critical knowledge gap: We know that these drugs work, but we do not know exactly In recent years, two groundbreaking drugs were discovered to fix G551D and Delta-F508: Kalydeco and Orkambi, respectively. Viirre are very optimistic about the current generation of drugs, but recognize the strong need to understand them on a deeper level.
This devastating disease, characterized by the destruction of the lungs and digestive system complications, is caused by defects in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and its protein.
CF is currently incurable, but new research is providing hope for better treatments—and, ultimately, a cure. Christine Bear from the Hospital for Sick Children and Dr.
Russell Viirre from Ryerson University are working in an interdisciplinary environment to improve CF treatments to further-increase the lifespans of patients of this deadly disease.
The Hollywood Reporter said the cause is believed to be a blood clot in his ankle.In 2005, the Canada Revenue Agency broadened eligibility criteria and added a 10-year retroactive refund for those who can prove their impairment has lasted for years. The federal tax agency has launched an investigation of Winnipeg-based J & J Canadian Grants Company on the suspicion its owners colluded with a local doctor to sign hundreds of phony medical certificates — including one for a working firefighter — claiming disabilities.Canada's largest tax company helping the disabled, the Toronto-based National Benefit Authority (NBA), appears to also be under scrutiny.Some of its clients have been receiving notices from the revenue agency demanding the return of tax refunds or asking for second opinions to certify impairments.The CRA won't confirm whether an investigation is underway due to confidentiality issues. On the NBA's website, the company promises to help Canadians with disabilities receive "the money they deserve" by helping them navigate the "bottlenecks" in the tax system to secure refunds up to ,000.